supplement to support vascular function and skin health with anti-inflammatory
and analgesic properties.*
plant product made from the bark of the European coastal pine (Pinus
maritima). Pycnogenol® pine bark extract is a concentrate of a special
class of bioflavonoids called proanthocyanidins. Pycnogenol® is standardized
to yield 42.5 mg (85%) proanthocyanidins in a 50 mg capsule.
Canali; Raffaella Comitato; Frank Schonlau; and Fabio Virgili investigated
the effects of Pycnogenol supplementation on the arachidonic acid pathway
in human polymorphonuclear leukocytes (PMNL) in response to an inflammatory
supplementation reduced leukotriene production but did not leave prostaglandins
unaltered, which we attribute to a decline of COX-2 activity in favor
show for the first time that Pycnogenol supplementation simultaneously
inhibits COX-2 and 5-LOX gene expression and reduces leukotriene biosynthesis
in human PMNL upon pro-inflammatory stimulation ex vivo.
pharmacology of Pycnogenol in humans involves COX-2 and 5-LOX mRNA expression
are commonly used to treat pain
an inducible enzyme that promotes inflammation, pain, and fever.
contains 50 mg Pycnogenol® (Pine Bark Extract), 42.5 mg Proanthocyanidins
ingredients: maltodextrin, gelatin, cellulose, water, vegetable stearate,
As a dietary supplement, take 2 capsules with breakfast and 2 capsules
with lunch for two weeks. Then take 2 capsules daily with breakfast.
* This statement
has not been evaluated by the Food and Drug Administration. This product
is not intended to diagnose, treat, cure, or prevent any disease.